Polymeric Antioxidants. III.

Antioxidants and Cancer III: Quercetin

Quercetin is a flavonoid molecule ubiquitous in nature. A number of its actions make it a potential anti-cancer agent, including cell cycle regulation, interaction with type II estrogen binding sites, and tyrosine kinase inhibition. Quercetin appears to be associated with little toxicity when administered orally or intravenously. Much in vitro and some preliminary animal and human data indicate...

Nanoencapsulated Polymeric Antioxidants in Combating Neuronal Oxidative Damage

which leads to the production of peroxides, an influx of calcium and ultimately causes cell death [5]. The disturbances in mitochondrial structure and function play major role for the pathophysiological phenomenon in neurodegenerative diseases and in the mechanism of neurodegeneration among aged individuals [6-8]. The rate of ROS generation in mitochondria increases gradually with ageing [8,9]....

Thiol-based antioxidants elicit mitochondrial oxidation via respiratory complex III.

Excessive oxidation is widely accepted as a precursor to deleterious cellular function. On the other hand, an awareness of the role of reductive stress as a similar pathological insult is emerging. Here we report early dynamic changes in compartmentalized glutathione (GSH) redox potentials in living cells in response to exogenously supplied thiol-based antioxidants. Noninvasive monitoring of in...

Polymeric aqua(glutarato)(hydrogen glutarato)lanthanum(III) monohydrate

Transactivation of genes encoding for phase II enzymes and phase III transporters by phytochemical antioxidants.

The induction of phase II enzymes and phase III transporters contributes to the metabolism, detoxification of xenobiotics, antioxidant capacity, redox homeostasis and cell viability. Transactivation of the genes that encode for phase II enzymes and phase III transporters is coordinatively regulated by activating transcription factors in response to external stimuli. Comprehensive studies indica...